What Is DNA Replicated From DNA - 800 Words

In cells, DNA is replicated from chromosomes with two points of regulation: a six protein complex forms at an origin and is activated by proteins that can modify others (Gambus et al, 2006; Labib, 2010; Zegerman and Diffley, 2006). This draws more proteins towards the origin for initiation to occur. Origins are specific DNA sequences where the two DNA strands are unwound for replication, creating fork-like structures (Labib, 2010). Origin unwinding occurs by the six protein complex mentioned with other initiator proteins and a four protein complex called GINS (Gambus et al, 2006). Another six protein complex called the Origin Recognition Complex orders these components at the origin (Takeda et al, 2005). DNA replication is then carried†¦show more content†¦The ability to create an artificial origin allows for more research into the start of replication including the protein involved (Takeda et al, 2005). DNA Replication Initiation One paper used bypassing proteins in the replicative process of yeast to find that modification of proteins Sld2 and Sld3 by a modifier protein is only required for replication activation (Zegerman and Diffley, 2006). Sld3 modification allows it to bind one end of a bridge-like protein Dpb11 while Sld2 binds the other. The Sld modifying protein modifies up to two hundred different proteins and is activated by other modifying proteins used earlier in the replication process and its levels are kept low in these earlier stages as to avoid replicating DNA too early (Labib, 2010; Zegerman and Diffley, 2006). This paper could have suggested a role for the Sld2/3-Dpb11 interaction but does provide greater insight into various modifying proteins’ functions in replication (Zegerman and Diffley, 2006). Gambus et al showed that in yeast GINS interacts with the initial six protein complex mentioned and many regulatory proteins, through multiple methods such as r elated to their mass, and investigated the interaction strengths by incremental inhibition of their bonding (Gambus et al, 2006). GINS positions these extra proteins around the six protein complex and allows their interaction for DNA unwinding and replication. Understanding GINSShow MoreRelatedEssay about The Question of Biology is Why?1518 Words   |  7 Pagesother things. As humans, we are comparative by nature—always wondering what is the best between multiple things (if it even is) and why. That is why we do it, ultimately. We feel that we must answer the question â€Å"Why?† In this biographical paper, I will be analyzing two very different processes: DNA Replication and the Polymerase Chain Reaction (PCR). It is that each of these individual processes carries much importance. 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